The Long-Term Use of Beta Glucan to Boost Your Immune System

Last updated December 21, 2022

Longevity, vitality, endurance – everyone wants long-term health, no matter the word you use for it. In fact, a recent poll found that around four out of five adults take some sort of dietary supplement every day (1). However, 75% percent of those people are taking supplements they either don’t need or that don’t actually boost their health.

When run-of-the-mill multivitamins are the norm – that is, ones that only contain small amounts of a cocktail of different nutrients – how do you find a quality supplement that can be added to your long-term daily routine and actually make a difference?

Enter: Beta Glucan.

As something that has been around – and studied – for decades, it makes a wonderful supplement for boosting your immune system in order to help you combat a variety of common ailments Americans face today.

Let’s discuss how this works, the benefits you could potentially see, and how long you need to take them to get results.

How Beta Glucan Works for a Better Immune System

A balanced immune system is vital for a long, quality life. In a look at the innate immune systems versus adaptive immune systems (spoiler alert: they work together, not against each other), the “innate immune system is the body's first line of defense against germs entering the body.”(2)  In other words, it protects you from bacteria, viruses, fungi, and toxins – all the things that could make you sick.

When the innate immune system is imbalanced or compromised, you become more susceptible to anything from infectious diseases to just feeling sluggish and down.

So while searching for the perfect supplement to boost how you feel in your long-term health, Beta Glucan is the best place to start. Why’s that? Beta Glucan is the world's most effective and scientifically proven immune-boosting super supplement with no known side effects. (3)

But first, how does it work?

When taken with an 8-oz glass of water, it passes through the stomach into the small intestine – aka the gut. There, there are small areas of cells called Peyer’s Patches. In the Peyer’s Patches, there are a lot of different cells which have the receptor for Beta Glucan and can transport it to other parts of the body.

Most importantly, the Beta Glucan is transported to your immune cells (called immunocytes). Beta Glucan can act like little additional “soldiers” to protect that line of defense.

Trained Immunity (TRIM)

To further understand how it works on your immune system, you can look at Trained Immunity (TRIM). This describes a functional reprogramming of these aforementioned innate immune cells.

Trained immunity is the ability of the innate immune system, or immune cells, to “remember” a first challenge or foreign invader and then respond faster and with more vigor when faced with that invader the second time around.

Something needs to stimulate the immune cells the first time around, however, in order to unlock this trained immunity. Current evidence has shown beta glucans can cause this direct stimulation of immune responses and act as “training agents” within the cells, helping them respond faster when combating foreign invaders.

As you can tell, this little supplement goes on quite a powerful journey to help boost your immune system and overall health.

So how does that benefit your everyday life, in layman’s terms?

Trained immunity is the ability of the innate immune system, or immune cells, to “remember” a first challenge or foreign invader and then respond faster and with more vigor

Long-Term Benefits of an Immune System Powered by Beta Glucan

It works through Natural Killer (NK) cells.

For context, Natural killer (NK) cells represent the first line of defense against infections to spontaneously kill virus-infected cells. Meanwhile, the effect Beta Glucan has on chronic illness has been studied, most notably stating that “as [an] immunostimulating agent, [it] acts through the activation of macrophages and NK cell cytotoxicity.” (4)

It’ll help shorten the common cold.

In two double-blind, placebo-controlled studies, “yeast-derived β-glucan was shown to significantly reduce the number of common cold episodes by 25% and led to a milder progression of severe common cold episodes.” (5)

It can be hypoglycemic.

Beta Glucan can become gel-like which slows down the digestion and absorption process. This, in turn, increases satiety – or that wonderful “full” feeling. In addition, short-chain fatty acids produced from bacteria that ferment Beta Glucan fibers may also increase satiety! (6)

It could help fight viruses and infections.

There are various studies, but it’s been shown that beta glucans can bolster the immune system to protect against infections, while a separate study at the same method can help reduce flu symptoms. (7)

It helps fight seasonal allergies.

Tired of drowse-inducing medications when it comes to allergy relief? Beta Glucan is a holistic solution to help support the immune system, which is key to regulating allergies caused by ragweed and cedar pollen. (8) (9)

It helps with recovery and endurance in athletes.

Any endurance athlete can relate to the cycle of intense training followed by intense illness. It turns out, there is a greater incidence of URTI among marathon runners. As we’ve reported before, a 2020 study found that marathon runners (with an ongoing history of URTI) who drank a beverage containing Baker’s Yeast beta glucan daily 45 days before the race and continuing for 45 days after, experienced fewer symptoms, including less nasal discharge and sore throat. (10)

It was also shown to help relieve Chronic Fatigue Syndrome, lower inflammation, and help with mental focus. That’s something all athletes could benefit from during training!

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How Long Does it Take for Beta Glucan to Work?

We have discussed these “long-term” health benefits of beta glucan, but now you may be wondering how long it actually takes to actually see results. What length of time are we talking about here? Your curiosity is understandable!

As mentioned in the very sophisticated processes of how Beta Glucan moves through your body, it takes about three days for your immune system to achieve a “peak” level thanks to the supplements. Although, you may feel an immediate influence on your immune system when you begin taking it.

It’s important to keep in mind that Beta Glucan is not a short-acting drug intended for immediate relief, such as when taking an anti-histamine for allergies or a Tylenol for a headache. As mentioned, it's a supplement intended to be taken daily in order to achieve its maximum benefits.

That’s because Beta Glucans remain in your digestive tract for a few days before flushing out. Once you stop taking beta glucan, the immune response returns to its original level of effectiveness – so it's an ongoing solution.

The Quality of Beta Glucan Matters When it Comes to Optimal Health

Not all forms or supplements of Beta Glucan are created equal. Beta Glucan in supplement form is divided by purity class. And here’s the kicker: only 10% of the supply is labeled as the “pure cut” for pure form.

A study done by the University of Louisville cross-compared hundreds of immune supplements for both potency and efficacy. (11) Better Way Health Beta Glucan was found to be the most effective. Including:

In other words, at Better Way Health, we are the sole owner of the purest Beta Glucan in the world! In fact, we test every batch to ensure such potency is retained.

If you’re not purchasing from us, you are getting the other 90% in terms of quality. That means both the quick and long-term effects of Beta Glucan just can’t be measured in the same way.

If you’re ready for pure and powerful Beta Glucan supplements that benefit your overall health, give us a try today.

Still have questions?

Our ACES Team is always there to help.

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6,910 verified 5-star reviews from happy, healthy customers just like you!

I just take 2 to 3 of these per day, if I feel like I'm going to be traveling or around grandkids who have sicknesses then I will take more. 

Tracy Compton

We started using Beta Glucans with My Son when he was 10 years old ... I would Definitely, Definitely Recommend Beta Glucan.

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I was watching a Series by Chris Wark and He Highly Recommended Beta Glucan.

Heather Mills

I'm gonna hit 71 years old in April... I mean I'm doing things that 40 year old's do. 

G.J. Rancourt

Try it ... Your Immune System is Boosted to a Level that Mine Has Never Seen in Years.

Darcy Waller

I Feel I Have More Energy, I Feel Stronger ... I Recommend Beta Glucan to Everyone.

Diana Perez

I have not missed a day taking My Beta Glucan and I'm Really Pleased with The Results

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I just want to endorse them and say they have a great product, but they are a great company with awesome people. 

Scott Wood


For more information about beta glucan, Better Way Health and more, visit our FAQ page. To speak to an Amazing Customer Experience Specialist, give us a call at 800.746.7640or email us at

For maximum immune response, take 1, 500mg capsule per 50 lbs. of body weight. For example, if you weigh around 150 lbs. you would need to take 3 capsules per day. All capsules should be taken first thing in the morning on an empty stomach. After taking your capsules, wait 30 minutes before eating or consuming other products. If you forget to take your capsules in the morning it is safe to go ahead and take your Beta Glucan during the day, although the benefits will not be as significant. Remember, these dosage instructions are for maximum immune response.

"For maximum immune response, take One 500mg capsule per 50 pounds of body weight."

Our Beta Glucan is made in Wisconsin, USA, and bottled/encapsulated in Oregon, USA.

Our highly purified Beta Glucan powder is encapsulated in a vegetarian capsule.

Our Beta Glucan does not contain nor is it manufactured with wheat, gluten, soy, corn, milk, egg, fish, nuts, or shellfish ingredients. However, it is produced in a GMP facility that processes other ingredients containing these allergens, but controls are in place to ensure there is no cross-contamination.

The short answer to that is Beta-1, 3D Glucan is a natural fiber molecule extracted from our source, baker’s yeast (Saccharomyces cerevisiae). It enhances, supports, and maintains a good healthy immune system.

The long and more complex answer is that it is a naturally occurring long-chain polysaccharide purified from the cell walls of baker’s yeast. Our beta glucan is intensely purified: I cannot stress that enough. It is a biologically active complex of molecules; it is the single active ingredient in our Beta-1, 3D Glucan Capsules. A lot of times, people think we are dipping from four or five different buckets to make up our powder. This (Beta 1-3D Glucan) is the single ingredient in our compound.

Our Beta Glucan is readily taken up and converted into the body through the immune cells to bind (or hook up or plug into, if you please) to a specific site on the immune cells called the CR3 receptor. CR3 stands for complement receptor number three. These receptors are found on a myriad of different immune cells that make up our white blood cells or our “immune army,” also known as macrophages, neutrophils, eosinophils, monocytes, NK cells, and others. These immune cells make up a large part of the immune system’s main defense mechanism.

Technically, Beta-1, 3D Glucan is a polybranched, polyglucose complex fiber-like particle that when converted, yields a biologically active beta glucan molecule that specifically binds to this CR3 (or sometimes called Mac1 or sometimes called CD11/C18).

-AJ Lanigan

Our Beta Glucan is actually considered an immunomodulator. For a substance or product to be an immunomodulator it cannot overstimulate or suppress your immune system. Most products that address the immune system are marketed as “immune boosters,” but that’s actually a misrepresentation of Beta Glucan. This product will never cause overstimulation or harm as it provides a healthy, safe immune response at any dosage. The same cannot be said for typical “immune boosters.” Beta Glucan makes your immune system smarter and stronger, which aids in identifying self and non-self cells better than ever before.

-Better Way Health

It is kind of a general term which I don’t even think is just to characterize it or anything like that. If it is natural it means the molecule has to come from a natural source because sometimes you can have a modulator that is completely synthetic, the term “immunomodulator” means that it is something that either in the plastic tube or in our body will modulate or change individual parts of the immune system so it works differently. You can basically consider even an immunosuppressive drug an immunomodulator because it modulates your system. It’s better to talk about if it is a stimulator or a suppressor. It is something that will affect the immune system and change its activities and abilities.

Yes, in our body we usually need a positive, we need stimulation. Only in cases like we talked about, auto-immune diseases and transplantation, do we need the opposite. We need to suppress the system so that the system is not fighting the new kidney.

It is something that is usually neglected but for a lot of our problems in the last decade, they are our problems. It’s a situation where we live, the conditions, how we live, what we eat, the pollution in the air, in our water, and so on. This is causing the diseases. It is common knowledge even about allergy diseases. There are dozens of studies from Iceland where for decades there were very few allergies in Iceland. They have no trees and the grasses they have don’t have the allergic pollen and so on. So the level of allergies in Iceland, particularly among kids was maybe 1/10th of what is found in Europe or the United States. In the last decade, the conditions changed there, they still don’t have trees and they still have the same grass, but they are eating differently, and they have bigger towns, factories, and so on. Now over the last two or three years, the level of allergies in Iceland’s kids is identical to Western Europe. If you change the condition or change the food you are just not as healthy as you used to be. So, we have to think about it, we can hardly change how clear the air will be. You might change the nutrition a little bit, you might change what you eat, we can go for better vegetables or something like that but the conditions of life will be the same and that is where the immunomodulator can come and help.

-Dr. Vaclav Vetvicka

Once you swallow your Beta Glucan capsules, the product enters the stomach. Shortly after, it is taken up into a special region known as the Peyer’s Patches. In the Peyer’s Patches, there are M cells, which transport the Beta Glucan to immune cells. These immune cells chew up the Beta Glucan and distribute it all over the body. The Beta Glucan fragments bind to Neutrophils, Macrophages, and Natural Killer cells. The binding of Beta Glucan to these cells is only possible with something known as the CR-3 Receptor. The CR-3 Receptor acts like a key unlocking a door. This binding of Beta Glucan with immune cells is what puts them on “high alert” priming them for action. In about 3 days after taking your Beta Glucan your immune system will be “fully activated.”

-Better Way Health

I would suggest chasing the Beta Glucan with a 4oz glass of water. Once the Beta Glucan goes down the esophagus, it passes into the stomach. Keep in mind that Beta Glucan is a complex carbohydrate, nature’s armor and that the stomach acid is not going to affect it at all. It will then pass from the stomach into the small intestine. The Beta Glucan microparticles are going to be seen and consumed by M-cells, or microfold cells, inside your Peyer’s Patches in your small intestine.

Think of the Peyer’s Patches as little Venus flytraps that physically reach up and grab these particles. They do not soak through the intestines. There is an actual grabbing of the particles which then pulls them through the lining of the intestine. Once inside these pockets, the particles are now inside the intestinal wall in what is called the GALT (Gut-Associated Lymphoid Tissue).

There are millions of immune cells sitting and sampling everything that comes through the gut and they are going to be attracted to the Beta Glucan; which holds the fingerprint of the yeast, yet it does not cause any of the reactions that yeast may cause. Once the particles are gobbled up and internalized, they will begin to travel throughout the body. They go to the lymph system through the lymph nodes and then into the liver; and soon into the kidneys, lungs, and bone marrow. 

-AJ Lanigan

It goes through the stomach basically unchanged because we cannot process this type of saccharide. Only horses and animals basically eating grass can do it. We cannot. So it goes through the stomach and inside the intestine there are small patches of cells called Peyer’s Patches and they have a lot of different cells inside which have the receptor for the glucan.

So when the glucan slowly passes through, they actively see the molecules of glucan, bind it, catch them, and suck them in. By doing it, now they have the glucan inside. They start slowly to chew it up into smaller parts, it leaves the Peyer’s Patches into the other organs of the body releasing the fragments and in this way, the glucan is slowly spreading around our body. And it takes a couple of days. That is why I said it takes three days to see any results because it goes from one organ to another, cells are, exchanging glucan molecules.

-Dr. Vaclav Vetvicka

There are numerous ways for consumers to know which beta glucan product is the best. First, you must know the source of the product and where it’s manufactured. Our Beta Glucan is derived from the cell walls of baker’s yeast and is manufactured in the U.S. Second, know the level of purity of the particular product. The minimum level of purity for our product is 85%, which provides the best immune response possible to the consumer. Finally, check and see if there’s peer-reviewed, disinterested 3rd party research on the product. Our Beta Glucan has hundreds of studies published by teaching hospitals and major universities like Harvard, Louisville, and Cornell proving its safety and efficacy.

-Better Way Health

You have to do your homework. If you just believe whatever you read on the Internet, you will probably be taken to the cleaners. First of all, you should never go for the cheapest product. We used to say back home, “You are not rich enough to buy the cheap stuff.” If is too cheap something is most probably wrong. So that is one thing which should warn you.

It doesn’t necessarily mean you have to buy the most expensive one because you could be buying a more expensive bottle than anything else. But don’t go for the cheap stuff. Second, really check the information. Because to the company, either the manufacturer or the reseller, it doesn’t really matter. If he takes the material and the whole situation seriously he will give you detailed information on how it’s made, how pure it is, how much you have in the pill, give you some links to the research based on THIS particle of glucan and NOT on the glucan somebody else made, on MY glucan.

If it is there and the information/research sounds good, you most probably have a good product. If somebody is showing information having a yeast glucan and you see the reference for mushroom glucan from Japan, what does it mean? He just took something from the Internet and put it on the web page. Do the homework, be careful and you will end up with the good stuff.

-Dr. Vaclav Vetvicka

Our Beta Glucan goes through a rigorous purification process developed by creator, AJ Lanigan. Once this purification process takes place only about 10% of a given “batch” meets our 85% minimum purity standard. The “scraps”, so to speak, are sold off and marketed by other companies. In addition, the product has been tested time and time again proving its efficacy. When compared to other heavily marketed immune system products it comes out on top every single time. Most of these studies are conducted by a disinterested third-party researcher at the University of Louisville. In these studies, immune response levels are safely tested on both humans and animals. Our product is also Non-GMO encased in a Vegan, plant-based capsule.

-Better Way Health

Better Way Health Beta Glucan 500 is certainly one of the most renowned brands out there in the marketplace. In our world of immune system support, when you ask “What’s the best immune system supplement out there?”; well, the Better Way Health name is the most recognized.

Anyone who has spent time reviewing side-by-side comparisons of our product with, again, just about any other kind of immune compound; regardless of the source, you’re going to find that our product outperforms all competitors. This has been for years; this is not a new phenomenon that conclusive research done by disinterested third parties in major universities, teaching hospitals here in the US, facilities in Europe, and the Far East have all agreed upon Our Beta Glucan's potency 100%.

It’s not like echinacea (or other stimulants), where half say it works and the other half disagrees. Across the board, you get unanimous agreement that Glucan 500 by Better Way Health is the brand in Immunity Support: “You’ve arrived, stop looking!”

-AJ Lanigan

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As COO of Better Way Health, Taylor creates and Implements business operations & policies that reinforce our company culture. He ensures we stick to our core values and provides resources to elevate our team members in their respective roles. He is the day-to-day backbone of our world-class customer service and a seasoned authority on Beta Glucan.

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